Article
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Neurobiology of disease - 1 Oct 2014
Yin Guowei, Lopes da Fonseca Tomas, Eisbach Sibylle E, Anduaga Ane Martín, Breda Carlo, Orcellet Maria L, Szegő Éva M, Guerreiro Patricia, Lázaro Diana F, Braus Gerhard H, Fernandez Claudio O, Griesinger Christian, Becker Stefan, Goody Roger S, Itzen Aymelt, Giorgini Flaviano, Outeiro Tiago F, Zweckstetter Markus
Abstract excerpt
Alpha-synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunction. Here we demonstrate that the GTPase Rab8a interacts with αS in rodent brain. NMR spectroscopy reveals that the C-terminus of αS binds to the functionally important...
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