Article
Rabs, SNAREs and α-synuclein--membrane trafficking defects in synucleinopathies.
Brain research reviews - 24 Jun 2011
Chua Christelle En Lin, Tang Bor Luen
Abstract excerpt
Neuronal dysfunctions and neurodegeneration are often associated with defects in membrane transport. Synucleinopathies are a diverse group of neurodegenerative disorders that share a common pathological feature--insoluble aggregates composed largely of the protein α-synuclein in certain populations of neurons and glia. The actual physiological function of the brain-enriched α-synuclein is still not particularly...
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