Article
Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0.
Biophysical journal - 14 Mar 2017
Saboe Patrick O, Rapisarda Chiara, Kaptan Shreyas, Hsiao Yu-Shan, Summers Samantha R, De Zorzi Rita, Dukovski Danijela, Yu Jiaheng, de Groot Bert L, Kumar Manish, Walz Thomas
Abstract excerpt
Compared to other aquaporins (AQPs), lens-specific AQP0 is a poor water channel, and its permeability was reported to be pH-dependent. To date, most water conduction studies on AQP0 were performed on protein expressed in Xenopus oocytes, and the results may therefore also reflect effects introduced by the oocytes themselves. Experiments with purified AQP0 reconstituted into liposomes are challenging because the...
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