Article
Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice.
Experimental physiology - 1 Mar 2000
Verkman A S, Yang B, Song Y, Manley G T, Ma T
Abstract excerpt
Aquaporin-type water channels are expressed widely in mammalian tissues, particularly in the kidney, lung, eye and gastrointestinal tract. To define the role of aquaporins in organ physiology, we have generated and analysed transgenic mice lacking aquaporins (AQP) 1, 3, 4 and 5. Multiple phenotype abnormalities were found in the null mice. For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.