High burden of variants of uncertain significance in early-onset colorectal cancer among indigenous African patients: a call for global research equity in cancer genetics

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) remains a significant global health challenge, with rising incidence among early-onset cases in low- and middle-income countries, including South Africa. However, comprehensive germline genetic data from indigenous African populations remain scarce. This study aimed to explore germline genetic factors contributing to early-onset CRC (eoCRC) in Indigenous African patients using...

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