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Article

Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.

The Journal of biological chemistry - 21 Apr 2017

Weems Juston C, Slaughter Brian D, Unruh Jay R, Boeing Stefan, Hall Shawn M, McLaird Merry B, Yasukawa Takashi, Aso Teijiro, Svejstrup Jesper Q, Conaway Joan W, Conaway Ronald C

Abstract excerpt

Elongin A performs dual functions as the transcriptionally active subunit of RNA polymerase II (Pol II) elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that ubiquitylates Pol II in response to DNA damage. Assembly of the Elongin A ubiquitin ligase and its recruitment to sites of DNA damage is a tightly regulated process induced by DNA-damaging agents and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28292928
DOI: 10.1074/jbc.C117.777946
PMCID: PMC5399097

Genes

CUL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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