Article
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
Molecular and cellular biology - 1 Sept 2005
Thorslund Tina, von Kobbe Cayetano, Harrigan Jeanine A, Indig Fred E, Christiansen Mette, Stevnsner Tinna, Bohr Vilhelm A
Abstract excerpt
Cockayne syndrome (CS) is a rare genetic disorder characterized as a segmental premature-aging syndrome. The CS group B (CSB) protein has previously been implicated in transcription-coupled repair, transcriptional elongation, and restoration of RNA synthesis after DNA damage. Recently, evidence for a role of CSB in base excision repair of oxidative DNA lesions has accumulated. In our search to understand the...
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