Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination

1 Nov 2011

Abstract excerpt

Mutations in Cockayne syndrome (CS) A and B genes (CSA and CSB) result in a rare genetic disease that affects the development and homeostasis of a wide range of tissues and organs. We previously correlated the degenerative phenotype of patients to the enhanced apoptotic response, exhibited by CS cells, which is associated with the exceptional induction of p53 protein, upon a variety of stress stimuli. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22032989
DOI: 10.4161/cc.10.21.17905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitinationPMID 22032989Read ↗

The emerging role of Cockayne group A and B proteins in ubiquitin/proteasome-directed protein degradation.Semantic proximity Read ↗

Interaction between the Cockayne syndrome B and p53 proteins: implications for agingSemantic proximity Read ↗

Cockayne Syndrome Group B (CSB): The Regulatory Framework Governing the Multifunctional Protein and Its Plausible Role in Cancer.Semantic proximity Read ↗

Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome miceSemantic proximity Read ↗

Role of Cockayne Syndrome B (CSB) Protein in Genome Maintenance in Human Cells under Oxidative StressSemantic proximity Read ↗

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

Repair of oxidatively generated DNA damage in Cockayne syndrome.Semantic proximity Read ↗

Cockayne Syndrome B protein (CSB): Linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisionsSemantic proximity Read ↗

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?Semantic proximity Read ↗

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescenceSemantic proximity Read ↗

Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation.Semantic proximity Read ↗

Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.