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Article

Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans.

Genetics - 1 May 2017

Kulalert Warakorn, Sadeeshkumar Harini, Zhang Ying K, Schroeder Frank C, Kim Dennis H

Abstract excerpt

Cell-nonautonomous effects of signaling in the nervous system of animals can influence diverse aspects of organismal physiology. We previously showed that phosphorylation of Ser49 of the α-subunit of eukaryotic translation initiation factor 2 (eIF2α) in two chemosensory neurons by PEK-1/PERK promotes entry of Caenorhabditis elegans into dauer diapause. Here, we identified and characterized the molecular...

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PMID: 28292919
DOI: 10.1534/genetics.117.200568
PMCID: PMC5419473

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