Article
Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.
The pharmacogenomics journal - 1 Jan 2018
Teitelbaum A M, Murphy S E, Akk G, Baker T B, Germann A, von Weymarn L B, Bierut L J, Goate A, Kharasch E D, Bloom A J
Abstract excerpt
A common haplotype of the flavin-containing monooxygenase gene FMO3 is associated with aberrant mRNA splicing, a twofold reduction in in vivo nicotine N-oxidation and reduced nicotine dependence. Tobacco remains the largest cause of preventable mortality worldwide. CYP2A6, the primary hepatic nicotine metabolism gene, is robustly associated with cigarette consumption but other enzymes contribute to nicotine...
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