Article
Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption.
Pharmacogenetics and genomics - 1 Mar 2014
Chenoweth Meghan J, Zhu Andy Z X, Sanderson Cox Lisa, Ahluwalia Jasjit S, Benowitz Neal L, Tyndale Rachel F
Abstract excerpt
The rates of nicotine metabolism differ widely, even after controlling for genetic variation in the major nicotine-metabolizing enzyme, CYP2A6. Genetic variants in an additional nicotine-metabolizing enzyme, flavin-containing monooxygenase (FMO)-3, and an obligate microsomal CYP-supportive enzyme, cytochrome P450 oxidoreductase (POR), were investigated. We examined the impact of FMO3 E158K and POR A503V before...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.