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Article

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.

Pharmacogenetics and genomics - 1 Feb 2013

Bloom A Joseph, Murphy Sharon E, Martinez Maribel, von Weymarn Linda B, Bierut Laura J, Goate Alison

Abstract excerpt

BACKGROUND: Flavin-containing monooxygenases (FMO) catalyze the metabolism of nucleophilic heteroatom-containing drugs and xenobiotics, including nicotine. Rare mutations in FMO3 are responsible for defective N-oxidation of dietary trimethylamine leading to trimethylaminuria, and common genetic variation in FMO3 has been linked to interindividual variability in metabolic function that may be substrate specific....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23211429
DOI: 10.1097/FPC.0b013e32835c3b48
PMCID: PMC4583063

Genes

FMO3
FMO1
FMO2

Provenance

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Related research

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Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.PMID 23211429Read ↗

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Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.Semantic proximity Read ↗

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Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism.Semantic proximity Read ↗

Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation.Semantic proximity Read ↗

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Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and diseaseSemantic proximity Read ↗

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Predicting Nicotine Metabolism Across Ancestries Using GenotypesSemantic proximity Read ↗

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