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Article

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.

Stem cells (Dayton, Ohio) - 1 Mar 2017

Stryjewska Agata, Dries Ruben, Pieters Tim, Verstappen Griet, Conidi Andrea, Coddens Kathleen, Francis Annick, Umans Lieve, van IJcken Wilfred F J, Berx Geert, van Grunsven Leo A, Grosveld Frank G, Goossens Steven, Haigh Jody J, Huylebroeck Danny

Abstract excerpt

In human embryonic stem cells (ESCs) the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global transcriptional regulatory network in these cell-fate decisions. We generated Zeb2 knockout (KO) mouse ESCs, subjected them as embryoid bodies (EBs) to neural and general differentiation and carried out temporal RNA-sequencing (RNA-seq) and reduced...

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PMID: 27739137
DOI: 10.1002/stem.2521
PMCID: PMC5396376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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