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Article

Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington disease

13 Feb 2007

Abstract excerpt

Huntington disease (HD) is a progressive neurodegenerative disorder characterized by emotional, cognitive, and motor dysfunctions. Aggregation of huntingtin is a hallmark of HD and, therefore, a crucial parameter for the evaluation of HD animal models. We investigated here the regional, cellular, and subcellular distribution of N-terminal huntingtin aggregates and associated neuropathological changes in the...

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PMID: 17299753
DOI: 10.1002/cne.21272

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