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A Novel Mouse Model for Late-Onset Retinal Degeneration (L-ORD) Develops RPE Abnormalities Due to the Loss of C1qtnf5/Ctrp5.

Advances in experimental medicine and biology - 1 Jan 2023

Borooah Shyamanga, Chekuri Anil, Pachauri Shikha, Sahu Bhubananda, Vorochikhina Marina, Suk John J, Bartsch Dirk-Uwe, Chavali Venkata R M, Jablonski Monica M, Ayyagari Radha

Abstract excerpt

Late-onset retinal degeneration (L-ORD) is an autosomal dominant macular dystrophy resulting from mutations in the gene CTRP5/C1QTNF5. A mouse model (Ctrp5+/-) for the most common S163R developed many features of human clinical disease. We generated a novel homozygous Ctrp5 gene knock-out (Ctrp5-/-) mouse model to further study the mechanism of L-ORD. The retinal morphology of these mice was evaluated by retinal...

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PMID: 37440053
DOI: 10.1007/978-3-031-27681-1_48

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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