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Article

Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration.

ASN neuro - 26 Nov 2013

Wang Yujuan, Subramanian Preeti, Shen Defen, Tuo Jingsheng, Becerra S Patricia, Chan Chi-Chao

Abstract excerpt

AMD (age-related macular degeneration) is a neurodegenerative disease causing irreversible central blindness in the elderly. Apoptosis and inflammation play important roles in AMD pathogenesis. PEDF (pigment epithelium-derived factor) is a potent neurotrophic and anti-inflammatory glycoprotein that protects the retinal neurons and photoreceptors against cell death caused by pathological insults. We studied the...

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Identifiers

PMID: 24160756
DOI: 10.1042/AN20130028
PMCID: PMC3840469

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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