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Article

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

18 Jul 2005

Abstract excerpt

Systemic autoimmune disease in humans and mice is characterized by loss of immunologic tolerance to a restricted set of self-nuclear antigens. Autoantigens, such as double-stranded (ds) DNA and the RNA-containing Smith antigen (Sm), may be selectively targeted in systemic lupus erythematosus because of their ability to activate a putative common receptor. Toll-like receptor 9 (TLR9), a receptor for CpG DNA, has...

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PMID: 16027240
DOI: 10.1084/jem.20050338

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