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Article

Mosaic chromosome Y loss and testicular germ cell tumor risk.

Journal of human genetics - 1 Jun 2017

Machiela Mitchell J, Dagnall Casey L, Pathak Anand, Loud Jennifer T, Chanock Stephen J, Greene Mark H, McGlynn Katherine A, Stewart Douglas R

Abstract excerpt

Studies have suggested mosaic loss of chromosome Y (mLOY) in blood-derived DNA is common in older men. Cohort studies investigating mLOY and mortality have reported contradictory results. Previous work found that a 1.6 Mb deletion of the AZFc region on the Y chromosome (the 'gr/gr' deletion) is associated with both male infertility and increased risk of testicular germ cell tumors (TGCT). We investigated whether...

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Share to Chromosome Deletion
Share to Chromosomes, Human, Y

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Association Studies

Share to Infertility, Male

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Share to Neoplasms, Germ Cell and Embryonal

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Source

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Identifiers

PMID: 28275244
DOI: 10.1038/jhg.2017.20
PMCID: PMC5444985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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