Article
The Y deletion gr/gr and susceptibility to testicular germ cell tumor.
American journal of human genetics - 1 Dec 2005
Nathanson Katherine L, Kanetsky Peter A, Hawes Rachel, Vaughn David J, Letrero Richard, Tucker Kathy, Friedlander Michael, Phillips Kelly-Anne, Hogg David, Jewett Michael A S, Lohynska Radka, Daugaard Gedske, Richard Stéphane, Chompret Agnés, Bonaïti-Pellié Catherine, Heidenreich Axel, Olah Edith, Geczi Lajos, Bodrogi Istvan, Ormiston Wilma J, Daly Peter A, Oosterhuis J Wolter, Gillis Ad J M, Looijenga Leendert H J, Guilford Parry, Fosså Sophie D, Heimdal Ketil, Tjulandin Sergei A, Liubchenko Ludmila, Stoll Hans, Weber Walter, Rudd Matthew, Huddart Robert, Crockford Gillian P, Forman David, Oliver D Timothy, Einhorn Lawrence, Weber Barbara L, Kramer Joan, McMaster Mary, Greene Mark H, Pike Malcolm, Cortessis Victoria, Chen Chu, Schwartz Stephen M, Bishop D Timothy, Easton Douglas F, Stratton Michael R, Rapley Elizabeth A
Abstract excerpt
Testicular germ cell tumor (TGCT) is the most common cancer in young men. Despite a considerable familial component to TGCT risk, no genetic change that confers increased risk has been substantiated to date. The human Y chromosome carries a number of genes specifically involved in male germ cell development, and deletion of the AZFc region at Yq11 is the most common known genetic cause of infertility. Recently, a...
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