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Article

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

1 Mar 2017

Abstract excerpt

Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanisms regulating senescence are not well characterized. Here, we find that ITGB3 (integrin beta 3 or β3) is regulated by the Polycomb protein CBX7. β3 expression accelerates the onset of senescence in human primary fibroblasts by activating the transforming growth factor β (TGF-β)...

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PMID: 28273461
DOI: 10.1016/j.celrep.2017.02.012

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