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Article

MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.

Cell stem cell - 6 May 2011

Abell Amy N, Jordan Nicole Vincent, Huang Weichun, Prat Aleix, Midland Alicia A, Johnson Nancy L, Granger Deborah A, Mieczkowski Piotr A, Perou Charles M, Gomez Shawn M, Li Leping, Johnson Gary L

Abstract excerpt

Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epithelial-mesenchymal transition (EMT). Here, we show that MAP3K4 controls the activity of the histone acetyltransferase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21549327
DOI: 10.1016/j.stem.2011.03.008
PMCID: PMC3091002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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