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Article

Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.

Communications biology - 28 Aug 2020

Shendy Noha Ahmed Mohammed, Raghu Deepthi, Roy Sujoy, Perry Charles Hamilton, Safi Adiba, Branco Miguel Ramos, Homayouni Ramin, Abell Amy Noel

Abstract excerpt

Coordinated gene expression is required for phenotypic switching between epithelial and mesenchymal phenotypes during normal development and in disease states. Trophoblast stem (TS) cells undergo epithelial-mesenchymal transition (EMT) during implantation and placentation. Mechanisms coordinating gene expression during these processes are poorly understood. We have previously demonstrated that MAP3K4-regulated...

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Identifiers

PMID: 32859943
DOI: 10.1038/s42003-020-01200-z
PMCID: PMC7455715

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