Article
Broad and Conserved Immune Regulation by Genetically Heterogeneous Melanoma Cells.
Cancer research - 1 Apr 2017
Neubert Natalie J, Tillé Laure, Barras David, Soneson Charlotte, Baumgaertner Petra, Rimoldi Donata, Gfeller David, Delorenzi Mauro, Fuertes Marraco Silvia A, Speiser Daniel E
Abstract excerpt
Although mutations drive cancer, it is less clear to what extent genetic defects control immune mechanisms and confer resistance to T-cell-based immunotherapy. Here, we studied the reactions of malignant and benign melanocyte lines to cytotoxic CD8+ T cells (CTL) using flow cytometry and gene expression analyses. We found rapid and broad upregulation of immune-regulatory genes, essentially triggered by...
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