Article
Use of human tissue to assess the oncogenic activity of melanoma-associated mutations.
Nature genetics - 1 Jul 2005
Chudnovsky Yakov, Adams Amy E, Robbins Paul B, Lin Qun, Khavari Paul A
Abstract excerpt
Multiple genetic alterations occur in melanoma, a lethal skin malignancy of increasing incidence. These include mutations that activate Ras and two of its effector cascades, Raf and phosphoinositide 3-kinase (PI3K). Induction of Ras and Raf can be caused by active N-Ras and B-Raf mutants as well as by gene amplification. Activation of PI3K pathway components occurs by PTEN loss and by AKT3 amplification....
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