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Article

Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control.

PloS one - 1 Jan 2017

Cobley David, Hálová Lenka, Schauries Marie, Kaczmarek Adrian, Franz-Wachtel Mirita, Du Wei, Krug Karsten, Maček Boris, Petersen Janni

Abstract excerpt

Tight coupling of cell growth and cell cycle progression enable cells to adjust their rate of division, and therefore size, to the demands of proliferation in varying nutritional environments. Nutrient stress promotes inhibition of Target Of Rapamycin Complex 1 (TORC1) activity. In fission yeast, reduced TORC1 activity advances mitotic onset and switches growth to a sustained proliferation at reduced cell size. A...

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Source

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Identifiers

PMID: 28273166
DOI: 10.1371/journal.pone.0172740
PMCID: PMC5342193

Genes

PIKFYVE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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