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Article

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.

Open biology - 1 Nov 2011

Ikai Nobuyasu, Nakazawa Norihiko, Hayashi Takeshi, Yanagida Mitsuhiro

Abstract excerpt

Target of rapamycin complexes (TORCs), which are vital for nutrient utilization, contain a catalytic subunit with the phosphatidyl inositol kinase-related kinase (PIKK) motif. TORC1 is required for cell growth, while the functions of TORC2 are less well understood. We show here that the fission yeast Schizosaccharomyces pombe TORC2 has a cell cycle role through determining the proper timing of Cdc2 Tyr15...

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Identifiers

PMID: 22645648
DOI: 10.1098/rsob.110007
PMCID: PMC3352084

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.PMID 22645648Read ↗

Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.Semantic proximity Read ↗

Fission yeast Tor2 promotes cell growth and represses cell differentiation.Semantic proximity Read ↗

Identification of TOR signaling complexes: more TORC for the cell growth engine.Semantic proximity Read ↗

The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.Semantic proximity Read ↗

Structure-based engineering of Tor complexes uncovers different roles of two types of yeast TORC1sSemantic proximity Read ↗

Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read ↗

The Role of Autophagy in Genome Stability through Suppression of Abnormal Mitosis under StarvationSemantic proximity Read ↗

Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes.Semantic proximity Read ↗

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.Semantic proximity Read ↗

TORC1 signaling is governed by two negative regulators in fission yeast.Semantic proximity Read ↗

Opposite Effects of Tor1 and Tor2 on Nitrogen Starvation Responses in Fission YeastSemantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

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