Article
A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis.
Genes & development - 15 Aug 2009
Singh Jaspal, Tyers Mike
Abstract excerpt
The coupling of environmental conditions to cell growth and division is integral to cell fitness. In Saccharomyces cerevisiae, the transcription factor Sfp1 couples nutrient status to cell growth rate by controlling the expression of ribosome biogenesis (Ribi) and ribosomal protein (RP) genes. Sfp1 is localized to the nucleus in rich nutrients, but upon nutrient limitation or target of rapamycin (TOR) pathway...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Antifungal Agents
- Cell Size
- DNA-Binding Proteins
- Drug Resistance, Fungal
- Gene Expression Regulation, Fungal
- Molecular Sequence Data
- Protein Binding
- Protein Serine-Threonine Kinases
- Protein Transport
- Regulon
- Ribosomes
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Signal Transduction
- Sirolimus