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Article

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.

Cellular and molecular life sciences : CMLS - 1 Jul 2017

Kazi Julhash U, Chougule Rohit A, Li Tianfeng, Su Xianwei, Moharram Sausan A, Rupar Kaja, Marhäll Alissa, Gazi Mohiuddin, Sun Jianmin, Zhao Hui, Rönnstrand Lars

Abstract excerpt

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue...

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Share to Extracellular Signal-Regulated MAP Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28271164
DOI: 10.1007/s00018-017-2494-0
PMCID: PMC5487891

Genes

FLT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.PMID 28271164Read ↗

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