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Article

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.

Oncotarget - 14 Feb 2017

Kazi Julhash U, Rupar Kaja, Marhäll Alissa, Moharram Sausan A, Khanum Fatima, Shah Kinjal, Gazi Mohiuddin, Nagaraj Sachin Raj M, Sun Jianmin, Chougule Rohit A, Rönnstrand Lars

Abstract excerpt

The type III receptor tyrosine kinase FLT3 is one of the most commonly mutated oncogenes in acute myeloid leukemia (AML). Inhibition of mutated FLT3 in combination with chemotherapy has displayed promising results in clinical trials. However, one of the major obstacles in targeting FLT3 is the development of resistant disease due to secondary mutations in FLT3 that lead to relapse. FLT3 and its oncogenic mutants...

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Source

Open in PubMed Open full text

Identifiers

PMID: 28086240
DOI: 10.18632/oncotarget.14577
PMCID: PMC5355336

Genes

FLT3
ABL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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