Article
Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.
PloS one - 1 Jan 2014
Janke Hanna, Pastore Friederike, Schumacher Daniela, Herold Tobias, Hopfner Karl-Peter, Schneider Stephanie, Berdel Wolfgang E, Büchner Thomas, Woermann Bernhard J, Subklewe Marion, Bohlander Stefan K, Hiddemann Wolfgang, Spiekermann Karsten, Polzer Harald
Abstract excerpt
About 30% of patients with acute myeloid leukemia (AML) harbour mutations of the receptor tyrosine kinase FLT3, mostly internal tandem duplications (ITD) and point mutations of the second tyrosine kinase domain (TKD). It was the aim of this study to comprehensively analyze clinical and functional properties of various FLT3 mutants. In 672 normal karyotype AML patients FLT3-ITD, but not FLT3-TKD mutations were...
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