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Article

Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.

Oncogene - 8 Dec 2005

Ishiko Jun, Mizuki Masao, Matsumura Itaru, Shibayama Hirohiko, Sugahara Hiroyuki, Scholz Glen, Serve Hubert, Kanakura Yuzuru

Abstract excerpt

FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues fo...

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Source

Identifiers

PMID: 16091740
DOI: 10.1038/sj.onc.1208957

Genes

FLT3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16091740-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.PMID 16091740Read ↗

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