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Article

Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice.

Lupus science & medicine - 1 Feb 2023

Petrova Tsvetana, Figueras-Vadillo Clara, Nanda Sambit K, Scudamore Cheryl, Cohen Philip

Abstract excerpt

OBJECTIVE: The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse. METHODS: ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet containing pacritinib. Body weight was monitored, and serum collected at the end to measure pacritinib, autoantibody and immunoglobulin levels. Splenic immune...

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Identifiers

PMID: 36822800
DOI: 10.1136/lupus-2022-000822
PMCID: PMC9950973

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