Article

Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer

2023-04-28

Abstract excerpt

Copy number variations, and particularly duplications of genomic regions, have been strongly associated with various neurodegenerative conditions including autism spectrum disorder (ASD). These genetic variations have been found to have a significant impact on brain development and function, which can lead to the emergence of neurological and behavioral symptoms. Developing strategies to target these genomic dupli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4baf8e0-3a7d-5a29-a7b3-76f0634fcbad
DOI: 10.1101/2023.04.28.538685

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse FlailerDOI 10.1101/2023.04.28.538685Read

Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse FlailerSemantic proximity Read

Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal SynapsesSemantic proximity Read

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERESemantic proximity Read

Autism in a dish: ES cell models of autism with copy number variations reveal cell-type-specific vulnerabilitySemantic proximity Read

Megabase-Scale Transgene De-Duplication to Generate a Functional Single-Copy Full-Length Human DMD Transgenic Mouse ModelSemantic proximity Read

The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning.Semantic proximity Read

Genes adapt to outsmart gene targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translationSemantic proximity Read

Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.Semantic proximity Read

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.Semantic proximity Read

Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafishSemantic proximity Read

Tunable, proteolytic dosage control of CRISPR-Cas systems enables precise gene therapy for dosage sensitive disordersSemantic proximity Read

RNA editing and death of motor neuronsSemantic proximity Read