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Article

HDAC inhibitors show differential epigenetic regulation and cell survival strategies on p53 mutant colon cancer cells.

Journal of biomolecular structure & dynamics - 1 Mar 2018

R Mahalakshmi, P Husayn Ahmed, Mahadevan Vijayalakshmi

Abstract excerpt

Besides inactivating tumour suppressor activity in cells, mutations in p53 confer significant oncogenic functions and promote metastasis and resistance to anticancer therapy. A variety of therapies involving genetic and epigenetic signalling events regulate tumorogenesis and progression in such cases. Pharmacological interventions with HDAC inhibitors have shown promise in therapy. This work explores the changes...

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Source

Identifiers

PMID: 28264628
DOI: 10.1080/07391102.2017.1302820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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