Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells

16 Jan 2025

Abstract excerpt

Epigenetic abnormalities play a critical role in colon carcinogenesis, making them a promising target for therapeutic interventions. In this study, we demonstrated that curcumin reduces colon cancer cell survival and that a decrease in lysine methylation was involved in such an effect. This correlated with the downregulation of methyltransferases EZH2, MLL1, and G9a, in both wild-type p53 (wtp53) HCT116 cells and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related Molecular Pathways
Share to Curcumin's Biomedical Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39860204
DOI: 10.3390/molecules30020335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer CellsPMID 39860204Read ↗

SelSA-1, a novel HDAC inhibitor demonstrates enhanced chemotherapeutic potential by redox modulationSemantic proximity Read ↗

N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNASemantic proximity Read ↗

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.Semantic proximity Read ↗

Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells.Semantic proximity Read ↗

Saffron and Its Major Ingredients’ Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite InstabilitySemantic proximity Read ↗

SETD3 is a positive regulator of DNA-damage-induced apoptosisSemantic proximity Read ↗

HDAC inhibitors show differential epigenetic regulation and cell survival strategies on p53 mutant colon cancer cells.Semantic proximity Read ↗

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancerSemantic proximity Read ↗

The impact of folate status on the efficacy of colorectal cancer treatment.Semantic proximity Read ↗

The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell linesSemantic proximity Read ↗

Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines.Semantic proximity Read ↗

Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.