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Article

TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents

29 May 2020

Abstract excerpt

Chemoresistance of colorectal cancer (CRC) leads to tumor recurrence and metastasis and new strategies are urgently needed to improve the outcomes of conventional chemotherapy. Sirtuin (SIRT) inhibitors prevent tumor cell growth by increasing the levels of acetylated histones and non‑histones, as well as disrupting survival‑related pathways. The aim of the present study was to determine the effect of SIRT...

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PMID: 32742376
DOI: 10.3892/etm.2020.8818

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