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Article

Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Aug 2018

Mascaro-Cordeiro Bruna, Oliveira Indhira Dias, Tesser-Gamba Francine, Pavon Lorena Favaro, Saba-Silva Nasjla, Cavalheiro Sergio, Dastoli Patrícia, Toledo Silvia Regina Caminada

Abstract excerpt

PURPOSE: Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB). In the present study, we investigated VA role, combined to cisplatin (CDDP) in cell viability and gene expression of MB cell lines. METHODS: Dose-response curve determined IC50 values for each treatment: (1) VA single, (2)...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebellar Neoplasms

Share to Dose-Response Relationship, Drug

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Source

Identifiers

PMID: 29785653
DOI: 10.1007/s00381-018-3817-7

Genes

TERT
PTCH1
GLI1
SHH
CTNNB1
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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