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Article

Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress.

Scientific reports - 6 Mar 2017

Gilmore Brian L, Liang Yanping, Winton Carly E, Patel Kaya, Karageorge Vasilea, Varano A Cameron, Dearnaley William, Sheng Zhi, Kelly Deborah F

Abstract excerpt

The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic instability and increased DNA lesions. Here, we used a combination of molecular imaging and biochemical tools to study the properties of the BRCA1 in human cancer cells. Our results reveal new...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28262780
DOI: 10.1038/srep43435
PMCID: PMC5338271

Genes

BRCA1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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