Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of BRCA1 RING domain variants: computationally derived structural data can improve upon experimental features for training predictive models.

Integrative biology : quantitative biosciences from nano to macro - 30 Sept 2020

Masso Majid

Abstract excerpt

Advancements in the interpretation of variants of unknown significance are critical for improving clinical outcomes. In a recent study, massive parallel assays were used to experimentally quantify the effects of missense substitutions in the RING domain of BRCA1 on E3 ubiquitin ligase activity as well as BARD1 RING domain binding. These attributes were subsequently used for training a predictive model of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Machine Learning
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Mutagenesis

Share to Neural Networks, Computer

Share to Predictive Value of Tests

Share to Protein Domains

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 32984879
DOI: 10.1093/intbio/zyaa019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of BRCA1 RING domain variants: computationally derived structural data can improve upon experimental features for training predictive models.PMID 32984879Read ↗

Structure-based functional analysis of BRCA1 RING domain variants: Concordance of computational mutagenesis, experimental assay, and clinical data.Semantic proximity Read ↗

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.Semantic proximity Read ↗

A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function.Semantic proximity Read ↗

Resolving the Functional Significance of <i>BRCA1</i> RING Domain Missense SubstitutionsSemantic proximity Read ↗

Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks.Semantic proximity Read ↗

Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface.Semantic proximity Read ↗

Saturation genome editing of <i>BARD1</i> resolves VUS and provides insight into BRCA1-BARD1 tumor suppressionSemantic proximity Read ↗

Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.Semantic proximity Read ↗

DNA repair function scores for 2172 variants in the BRCA1 amino-terminus.Semantic proximity Read ↗

Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules.Semantic proximity Read ↗

DNA Repair Function Scores for 2172 Variants in the BRCA1 Amino-TerminusSemantic proximity Read ↗

Functional analysis and clinical classification of 462 germline BRCA2 missense variants affecting the DNA binding domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.