Article
Gene–environment interactions in asthma and allergy: the end of the beginning?
2 Mar 2010
Abstract excerpt
PURPOSE OF REVIEW: The pathogenesis of asthma and allergy typically involves not only distinct genetic and environmental factors, but also interactions between the two. Innate-immunity genes [particularly CD14, toll-like receptor (TLR)4 and TLR2, the critical mediators of responses to bacteria in the extracellular space] play a prominent role in gene-environment interactions relevant to asthma-related phenotypes...