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Integrated analyses of murine breast cancer models reveal critical parallels with human disease

22 Jul 2019

Abstract excerpt

Mouse models have an essential role in cancer research, yet little is known about how various models resemble human cancer at a genomic level. Here, we complete whole genome sequencing and transcriptome profiling of two widely used mouse models of breast cancer, MMTV-Neu and MMTV-PyMT. Through integrative in vitro and in vivo studies, we identify copy number alterations in key extracellular matrix proteins...

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PMID: 31332182
DOI: 10.1038/s41467-019-11236-3

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