Article
Rhesus macaque IFITM3 gene polymorphisms and SIV infection.
PloS one - 1 Jan 2017
Winkler Michael, Gärtner Sabine, Wrensch Florian, Krawczak Michael, Sauermann Ulrike, Pöhlmann Stefan
Abstract excerpt
Interferon-induced transmembrane proteins (IFITMs) have been recognized as important antiviral effectors of the innate immune system, both in cell culture and in infected humans. In particular, polymorphisms of the human IFITM3 gene have been shown to affect disease severity and progression in influenza A virus (FLUAV) and human immunodeficiency virus (HIV) infection, respectively. Rhesus macaques (Macaca...
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