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MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress

1 May 2017

Abstract excerpt

Significance Currently, there is no effective treatment for blindness resulting from loss of photoreceptors in humans. Elucidating degenerative pathways in photoreceptors may thus facilitate therapeutic strategies. Myocyte enhancer factor 2d (MEF2D) is a transcription factor known to be important for photoreceptor survival. Here, we explore the impact of low-level environmental light exposure on photoreceptor...

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PMID: 28461502
DOI: 10.1073/pnas.1613067114

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