Article
Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.
Cellular immunology - 1 Jun 2020
Liu Zhengyang, Liu Yuan, Li Ting, Wang Pingzhang, Mo Xiaoning, Lv Ping, Ma Dalong, Han Wenling
Abstract excerpt
B-1a cells represent a distinct B cell population with unique phenotype, self-renewing capacity and restricted Igμ repertoire. They primarily locate in body cavity and also exist in spleen. The different subpopulations of B-1a cells are heavily affected by local environment. Our previous studies revealed that MARVEL-domain-containing membrane protein, CMTM7, was involved in B-1a cell development. Here, we focused...
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