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Differential B‐lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1

19 Aug 2010

Abstract excerpt

CD40 plays a vital role in humoral immunity, via its potent and multifaceted function as an activating receptor of various immune cells, most notably B lymphocytes. The Epstein-Barr virus-encoded transforming protein latent membrane protein 1 (LMP1) serves as a functional mimic of CD40 signals to B cells but lacks key regulatory controls that restrain CD40 signaling. This allows LMP1 to activate B cells in an...

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PMID: 20727039
DOI: 10.1111/j.1600-065x.2010.00932.x

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