Article
Detection of PIK3CA Mutations in Plasma DNA of Colorectal Cancer Patients by an Ultra-Sensitive PNA-Mediated PCR.
Molecular diagnosis & therapy - 1 Aug 2017
Zeng Qian, Xie Li, Zhou Na, Liu Min, Song Xianrang
Abstract excerpt
BACKGROUND: Mutant Phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) has been shown to be associated with the occurrence, development and prognosis in colorectal cancer (CRC). However, its detection has been limited because of complicated procedures and the low sensitivity of the present approaches. METHODS: We established an ultra-sensitive peptide nucleic acid-mediated polymerase...
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