Article
[Correlation analysis between abundance of K-ras mutation in plasma free DNA and its correlation with clinical outcome and prognosis in patients with metastatic colorectal cancer].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Sept 2013
Bai Yan-qing, Liu Xiao-jing, Wang Yan, Ge Fei-jiao, Zhao Chuan-hua, Fu Ya-li, Lin Li, Xu Jian-ming
Abstract excerpt
OBJECTIVE: To detect K-ras gene mutations in plasma free DNA by peptide nucleic acid clamp PCR assay (PNA-PCR) and nested primer PCR, and to analyze the correlation between K-ras mutations and prognosis in patients with metastatic colorectal cancer (mCRC). METHODS: Peripheral blood was collected and free DNA was extracted from plasma in 106 patients with mCRC. Nested primer PCR and PNA-PCR were used to detect...
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