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Article

Mood disorders and 5-HTR2A genetic variants - the moderator effect of inflammation on expression of affective polarity phenotype.

BMC psychiatry - 29 Oct 2024

Pantovic-Stefanovic Maja, Karanovic Jelena, Jurisic Vladimir, Dunjic-Kostic Bojana, Nesic Milica, Dodic Sara, Gostiljac Marta, Puric Marija, Savic Pavicevic Dusanka, Ivkovic Maja

Abstract excerpt

BACKGROUND: Although repeatedly confirmed, the molecular nature of gene-environment (GxE) interactions has rarely been investigated in the clinical context of mood disorders. This study assesses the relationship between HTR2A genetic variants and the modulatory effect of inflammation in a collective cohort of patients with major depressive disorder (MDD) and bipolar disorder (BD), as a unified group with two...

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Identifiers

PMID: 39472813
DOI: 10.1186/s12888-024-06207-y
PMCID: PMC11520582

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