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NRG1, PIP4K2A, and HTR2C as Potential Candidate Biomarker Genes for Several Clinical Subphenotypes of Depression and Bipolar Disorder

25 Aug 2020

Abstract excerpt

In the present study NRG1, PIP4K2A, HTR2C, GSK3B, BDNF, and NGF were analyzed by sequencing a cohort of 19 patients with bipolar affective disorder, 41 patients with recurrent depressive disorder, and 55 patients with depressive episode. A number of genetic variants were found to be associated with antidepressant treatment response, time to recurrence of episodes, and depression severity. Namely, alleles of...

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PMID: 33193575
DOI: 10.3389/fgene.2020.00936

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