Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2022

Du Yan, Cao Manlin, Liu Yiwen, He Yiqing, Yang Cuixia, Zhang Guoliang, Fan Youben, Gao Feng

Abstract excerpt

Hyaluronan (HA) is dynamically remodeled in tumor microenvironment (TME) and is reported to be closely related to tumor lymphatic metastasis by inducing lymphangiogenesis. Macrophages are known to be involved in neo-lymphatic vessels formation. However, few studies have investigated the role of HA-mediated TME remodeling on macrophages-dependent lymphangiogenesis. We previously showed that HA could drive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Hyaluronic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphangiogenesis

Share to Lymphatic Vessels

Share to Macrophages

Share to Phenotype

Share to Tumor Microenvironment

Source

Identifiers

PMID: 35239213
DOI: 10.1096/fj.202101230R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis.PMID 35239213Read ↗

Detection of PD-L1-expressing myeloid cell clusters in the hyaluronan-enriched stroma in tumor tissue and tumor-draining lymph nodesSemantic proximity Read ↗

Tumor-Associated EDA-FN-Enriched Matrix Instructs Macrophage BehaviorSemantic proximity Read ↗

Tumor-associated macrophages of the M1/M2 phenotype are involved in the regulation of malignant biological behavior of breast cancer cells through the EMT pathway.Semantic proximity Read ↗

Modulating Three-Dimensional Microenvironment with Hyaluronan of Different Molecular Weights Alters Breast Cancer Cell Invasion BehaviorSemantic proximity Read ↗

LYVE-1–expressing Macrophages Modulate the Hyaluronan-containing Extracellular Matrix in the Mammary Stroma and Contribute to Mammary Tumor GrowthSemantic proximity Read ↗

Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasisSemantic proximity Read ↗

Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironmentSemantic proximity Read ↗

In vitro elucidation of the role of pericellular matrix in metastatic extravasation and invasion of breast carcinoma cells.Semantic proximity Read ↗

Identification of Hyal2-expressing tumor-associated myeloid cells in cancer: implications for cancer-related inflammation through enhanced hyaluronan degradationSemantic proximity Read ↗

Hyaluronan-Cell Interactions in Cancer and Vascular DiseaseSemantic proximity Read ↗

The regulatory effect of hyaluronan on human mesenchymal stem cells’ fate modulates their interaction with cancer cells in vitroSemantic proximity Read ↗

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.